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  • One hundred years ago, German psychiatrist Alois Alzheimer first described the puzzling symptoms now known as Alzheimer's disease. Billions of dollars have since gone to research for a cure, but some scientists think that money is better spent on prevention and care.
  • White House officials defended the withdrawal from Afghanistan while taking questions from reporters Tuesday for the first time since Kabul was taken by the Taliban.
  • Europe's debt crisis seems to grow more dire every day as borrowing coasts for Spain and Italy soar. Germany's Chancellor Angela Merkel holds the purse strings, and says that although saving the single European currency will be a Herculean task, it must be done.
  • Weekend Edition guest host Don Gonyea talks to Leslie Harris, associate professor of history at Emory University, about the controversy triggered by Emory President James Wagner's praise for the "three-fifths compromise" of the U.S. Constitution. The notorious measure decreed that slaves were three-fifths of a person.
  • Singer-songwriter Carole King started young: She was just 15 when she founded a doo-wop group with her classmates. The act never took off, but King eventually became one of the biggest-selling artists of all time. She tells the story of her career so far in a new memoir, A Natural Woman.
  • Much of today's best Latin jazz embraces old traditions to create something new. NPR Producer Felix Contreras spotlights five female singers whose sounds borrow equally from Latin music and jazz.
  • Fresh Air jazz critic Kevin Whitehead picks CDs, books and a DVD for the jazz lover on your list this holiday season. His selections include a book of Sonny Rollins photographs and music from the first season of the HBO series Treme.
  • NPR Music's Tom Huizenga and host Guy Raz spin an eclectic mix of new classical releases.
  • In a tight Senate race in Maine, opponents of Republican Sen. Susan Collins are focusing on her role in crafting a 2006 law that they allege has crippled the Postal Service's finances.
  • This week saw two big music releases: a new album from pop baritone Josh Groban and the new download from mash-up genius Girl Talk. Music critic Tom Moon offers his thoughts on two very different albums.
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